A novel Weight Management Formula,
and we've got the data to prove it works!
3 powerful ingredients in one formula for:
Increased fat breakdown*
Increased fat burning*
Insulin modulating activity*
Reduced body weight*
* Data show increased lipolysis (fat breakdown) from improved adiponectin levels, increased thermogenesis (fat burning activity) and insulin modulating
activity resulting in reduced body weight, reduced BMI (Body Mass Index) and reduced waist-to hip circumference. These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
CardioMetabolic Lean by CardioMender, MD Nutraceuticals is a novel weight management formula that includes three branded and clinically studied ingredients-- Meratrim™ plant extract, Capsimax™ capsicum extract, and Zychrome® chromium complex. This special combination of ingredients may improve lipolysis (fat breakdown), thermogenic activity (fat burning activity), and insulin function†. The ingredients in CardioMetabolic Lean also help to increase adiponectin levels which facilitate proper fat metabolism and glucose regulation†.
Meratrim™ is a proprietary plant extract blend for weight management derived from two plants, Sphaeranthus indicus and Garcinia mangostana, traditionally used in Southeast Asian culture. Meratrim has been shown in two independent, randomized, double-blind, placebo-controlled clinical studies to significantly reduce body weight, BMI, and waist circumference within 8 weeks when used in combination with a diet and exercise plan†. Meratrim appears to achieve this by modulating the accumulation of fat while simultaneously increasing fat burning†. Toxicological studies on Meratrim have demonstrated a wide margin of safety.
In vitro studies demonstrate that Meratrim modulates the expression of biomarkers that control adipogenesis and lipogenesis as follows:
• Reduces the expression of the peroxisome proliferator-activated receptor gamma (PPAR) hormone receptor. PPAR induces adipocyte-specific genes involved in the formation and growth of fat cells†.
• Reduces the expression of adipocyte differentiation related protein (ADRP). This is a signaling protein which facilitates the uptake of fatty acids to form lipid droplets and adipocyte differentiation†.
• Reduces the expression of cluster of differentiation 36 (CD36)—a trans-membrane receptor that facilitates fatty acid uptake by adipocytes†.
• Reduces perilipin expression†. Perilipins are adipocyte proteins that are localized at the surface of the lipid droplet and inhibit fat break down by restricting access of lipase to the lipid droplet.
Capsimax™ capsicum extract is a proprietary encapsulated form of premium, highly concentrated natural capsicum fruit extract manufactured from hot red peppers. Capsaicinoids are a group of compounds which cause the “heat” found in hot peppers. In fact, over the past 30 years, studies including animal and human subjects support the potential of red hot capsicum and capsaicinoids as a safe, effective ingredient to aid in weight management†. Benefits of capsicum and capsaicinoids in animal and human studies have shown that it helps manage appetite, supports lipolysis, and helps diet-induced thermogenesis.† Capsimax™ is a patent-pending encapsulated form of premium, highly concentrated natural capsicum extract. Using a proprietary matrix, Capsimax capsicum extract gives users the maximum effectiveness of capsaicinoids without any oral or gastric irritation, thus solving the problem of capsicum compliance.
Zychrome™ is a unique, patent-pending chromium complex consisting of chromium, niacin and L-cysteine (chromium dinicocysteinate). Seventeen chromium complexes were screened in preclinical studies in order to arrive at the complex found in Zychrome™. In vitro and in vivo studies demonstrated that Zychrome is more efficacious than other forms of chromium in supporting healthy fasting glucose levels, glycated hemoglobin levels (HbA1c), insulin levels, CRP, MCP-1, ICAM-1 and oxidative stress levels†. These effects of Zychrome are mediated by the regulation of cell signal transduction pathways associated with insulin function, glucose control and vascular inflammation†. A randomized, double-blind, placebo-controlled clinical study showed that Zychrome significantly modulated the levels of insulin and insulin resistance as well as the inflammatory cytokine TNF and protein carbonyl content, a marker of oxidative stress. Toxicological studies have demonstrated a wide margin of safety.
CardioMetabolic Lean is indicated as a dietary supplement for individuals desiring weight management support.
Serving Size: 1 vegetarian capsule
Amount Per Serving
(as Chromium Dinicocysteinate)
Meratrim™ Proprietary Blend ...................400 mg
(Sphaerantus indicus extract, Garcinia mangostana extract)
(from Capsimax™, providing capsaicin, dihydrocapsaicin, nordihydrocapsaicin)
Other Ingredients: Hydroxypropyl methylcellulose (capsule), dicalcium phosphate, cellulose, vegetable stearate, pharmaceutical glaze and silica
Zychrome® is a trademark of InterHealth N.I.
Meratrim™ brand proprietary blend of two natural plant extracts. Meratrim™ is exclusively distributed by InterHealth N.I
Capsimax™ is a trademark of OmniActive Health Technologies.
Adults take 1 capsule 30 minutes before breakfast and 1 capsule 30 minutes before dinner, or as directed by your health care professional.
Gastrointestinal side effects such as bloating and flatulence may occur.
WARNING: If you are pregnant or nursing, consult a physician prior to use.
Store in a cool, dry place, away from direct light. Keep out of reach of children.
Durainpandiyan V, Kannan P, Ignacimuthu S. Antimicrobial activity of Sphaearanthus Indicus. L. Ethnobotanical Leaflets. 2009;13:422-430.
Jung HA, Su BN, Keller WJ, Mehta RG, Kinghorn AD. Antioxidant xanthones from the pericarp of Garcinia mangostana (mangosteen). J Agric Food Chem. 2006;54:2077-2082.
Stern JS, et al. (2011). Manuscript in preparation.
Lau FC, Golakoti T, Krishnaraju AV, Sengupta K, Bagchi D. FASEB J (Abstract Supplement). 2011;25:601.9.
Lau FC, Golakoti T, Krishnaraju AV, Sengupta K. Obesity J (Abstract Supplement). 2011;19:S175-590-P.
Trimurtulu G, et al. (2011) Manuscript in preparation.
Jain SK, Croad JL, Velusamy T, Rains JL, Bull R. Chromium dinicocysteinate supplementation can lower blood glucose, CRP, MCP-1, ICAM-1, creatinine, apparently mediated by elevated blood vitamin C and adiponectin and inhibition of NF-κB, Akt, and Glut-2 in livers of zucker diabetic fatty rats. Mol Nutr Food Res. 2010;54:1-10.
Jain SK, et al. The effect of chromium dinicocysteinate on insulin levels and oxidative stress: results from a randomized, double-blind, placebo-controlled clinical study. Manuscript in preparation.
Sreejayan N, Marone PA, Lau FC, Yasmin T, Bagchi M, Bagchi D. Safety and toxicological evaluation of a novel chromium(III) dinicocysteinate complex. Toxicol Mech Meth. 2010;20:321-333.
Yoshioka M, Lim K, Kikuzato S, Kiyonaga A, Tanaka H, Shindo M, Suzuki M. Effects of red-pepper diet on the energy metabolism in men. J Nutr Sci Vitaminol (Tokyo). 1995 Dec;41(6):647-56.
Yoshioka M, Doucet E, Drapeau V, Dionne I, Tremblay A. Combined effects of red pepper and caffeine consumption on 24 h energy balance in subjects given free access to foods. Br J Nutr. 2001 Feb;85(2):203-11.
Tsi D, Nah AK, Kiso Y, Moritani T, Ono H. Clinical study on the combined effect of capsaicin, green tea extract and essence of chicken on body fat content in human subjects. J Nutr Sci Vitaminol (Tokyo). 2003 Dec;49(6):437-41.
Bloomer et al. Effect of oral intake of capsaicinoid beadlets on catecholamine secretion and blood markers of lipolysis in healthy adults. Lipids in Health and Disease 2010, 9:72
† These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.