CardioMetabolic Lean

CardioMetabolic Lean

A novel Weight Management Formula,
and we've got the data to prove it works!

3 powerful ingredients in one formula for:

3 Actions:
Increased fat breakdown*
Increased fat burning*
Insulin modulating activity*

3 Outcomes:
Reduced body weight*
Reduced BMI*
Reduced Waist*

* Data show increased lipolysis (fat breakdown) from improved adiponectin levels, increased thermogenesis (fat burning activity) and insulin modulating
activity resulting in reduced body weight, reduced BMI (Body Mass Index) and reduced waist-to hip circumference.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

DESCRIPTION
CardioMetabolic Lean by CardioMender, MD Nutraceuticals is a novel healthy weight management† formula that includes three clinically studied ingredients: Meratrim® plant extract, Capsimax™ capsicum extract and chromium picolinate. This special combination of ingredients may support lipolysis (fat breakdown), thermogenic activity (fat burning activity) and insulin function. The ingredients in Metabolic Lean may also help promote adiponectin levels which facilitate healthy fat metabolism and glucose regulation. ‡

FUNCTIONS AND MECHANISM OF ACTION
Meratrim®
Meratrim® is a proprietary plant extract blend for weight management derived from two plants, Sphaeranthus indicus and Garcinia mangostana, traditionally used in Southeast Asian culture. Meratrim® has been shown in two independent, randomized, double-blind, placebo-controlled clinical studies to significantly reduce body weight, BMI, and waist circumference within 8 weeks when used in combination with a diet and exercise plan†. Meratrim® appears to achieve this by modulating the accumulation of fat while simultaneously supporting lipolysis. 

In vitro studies demonstrate that Meratrim® modulates the expression of biomarkers that control adipogenesis and lipogenesis as follows: ‡
• Active in the expression of the peroxisome proliferator-activated receptor gamma (PPAR) hormone receptor. PPAR regulates adipocyte-specific genes involved in the formation and growth of fat cells.
• Active in the expression of adipocyte differentiation related protein (ADRP). This is a signaling protein which facilitates the uptake of fatty acids to form lipid droplets and adipocyte differentiation.
• Active in the expression of cluster of differentiation 36 (CD36)—a trans-membrane receptor that facilitates fatty acid uptake by adipocytes.

Capsicum
Capsimax™ capsicum extract is a proprietary encapsulated form of premium, highly concentrated natural capsicum fruit extract manufactured from hot red peppers. Capsaicinoids are a group of compounds which cause the “heat” found in hot peppers. The benefits of capsicum and capsaicinoids in animal and human studies have shown that it helps moderate appetite, supports healthy metabolism and helps induce thermogenesis. Capsimax™ is a patent-pending encapsulated form of premium, highly concentrated natural capsicum extract. Using a proprietary matrix, Capsimax™capsicum extract gives users the maximum effectiveness of capsaicinoids without any oral or gastric irritation, thus solving the problem of capsicum compliance. ‡

Chromium
Chromium is an essential mineral that supports insulin function by activating insulin-dependent kinase activity. Several clinical trials suggest low-dose supplementation (<200ug/day) may support glucose homeostasis. ‡

INDICATIONS

CardioMetabolic Lean is indicated as a dietary supplement for healthy weight management support†‡ 

FORMULA (#202575)
Serving Size: 1 vegetarian capsule
Amount Per Serving
Chromium................................................100 mcg
(as Chromium picolinate)
Meratrim® Proprietary Blend ...................400 mg
(Sphaerantus indicus [flower heads] extract, Garcinia mangostana [fruit rind] extract)
Capsaicinoids.............................................1 mg
(from Capsimax™, providing capsaicin, dihydrocapsaicin, nordihydrocapsaicin)

Other Ingredients: Microcrystalline cellulose, hydroxypropyl methylcellulose (capsule), vegetable stearate and silica.
Meratrim® is a Laila Nutraceuticals trademark
Capsimax™ is a trademark of OmniActive Health Technologies
Gluten-free, Non-GMO 

SUGGESTED USE
Adults take 1 capsule 30 minutes before breakfast and 1 capsule 30 minutes before dinner, or as directed by your health care professional.

WARNING
Gastrointestinal side effects such as bloating and flatulence may occur.

If you are pregnant or nursing, consult a physician prior to use. If you are pregnant, nursing, have any health condition or taking any medication, consult your health professional before using this product.
Keep out of reach of children.

STORAGE
Store in a cool, dry place, away from direct light. Use only if safety seal is intact.

REFERENCES

Bloomer RJ, Canale RE, Shastri S, Suvarnapathki S. Lipids Health Dis. 2010 Jul 15;9:72.

Bumrungpert A, et al. J Nutr. 2009 Jun;139(6):1185-91.

Hochkogler CM, et al. Mol Nutr Food Res. 2014 Jun;58(6):1282-90.

Jain SK, et al. Mol Nutr Food Res. 2012 Aug;56(8):1333-41.

Janssens PL, Hursel R, Westerterp-Plantenga MS. Appetite. 2014 Jun;77:44-9.

Kudiganti V, et al. Lipids Health Dis. 2016 Aug 24;15(1):136.

Ramachandran S, et al. Evid Based Complement Alternat Med. 2011;2011. pii: 571721.

Saiyed ZM, Lugo JP. Food Nutr Res. 2016 Sep 28;60:31762.

Stern JS, et al. Obesity. 2013;21:921-927.

Taher M, et al. BMC Complement Altern Med. 2016 May 21;16:135.

Urbina SL, et al. Appetite. 2017 Jun 1;113:264-273.

Vincent JB. J Am Coll Nutr 18:6–12, 1999

Jovanovic L, Gutierrez M, Peterson CM. J Trace Elem Exp Med 12:91–97, 1999

Bahijri SM, Mira SA, Mufti AM, Ajabnoor MA. Saudi Med J 21:831–837, 2000

Ravina A, Slezak L, Rubal A, Mirsky N. J Trace Elem Exp Med 8:183–190, 1995

†Provides weight management support as part of a healthy lifestyle with a reduced-calorie diet and regular exercise.
‡These statements have not been evaluated by the Food and Drug Administration.
This product is not intended to diagnose, treat, cure, or prevent any disease.